antibiotics
MIC: minimum inhibitory concentration, minimum Concerto, from entering a bacteriostatic inhibition
MBK : minimum bactericidal concentration, lowest Concerto for killing at least 99.9% v.
success if concentration is> at the infection MIC; -> sensitive pathogens
comparison MIC / achievable drug concentration = Grundlagae bacteriological resistance determination
"overly sensitive" MIC only by high (yet recommended) dosage reached
provision Näherungswete, eg Plasmakonz BUT: some enrichment in phagocyting. Cells -> also at the site of infection in rel. high concentrations! -> Va macrolides, fluoroquinolones, macrolides and fluoroquinolones
accumulate in phagocyting cells.
important antibiotic targets:
cell wall synthesis : beta-lactams, glycopeptides
cytoplasmic : polymyxin B, colistin
ribosomal protein synthesis :
- a) inhibiting: Chloramphenicol, tetracyclines, macrolides, lincomycin
- b lack steering) : aminoglycosides
folic acid synthesis: sulphonamides, trimethoprim
RNA synthesis : Rifampicin
DNA replication: Quinolones
important antibiotic targets:
cell wall synthesis
cytoplasmic
protein synthesis (inhibitory / failed steering)
RNA synthesis
DNA replication
folic acid synthesis
important antibiotic targets:
cytoplasmic
cell wall synthesis
RNA synthesis
dna replication
folic acid synthesis
ribosomal protein synthesis (lack controlling / inhibiting) cell wall synthesis
: beta-lactams, glycopeptides cytoplasmic
: polymyxin B, colistin
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